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LETTER TO NIMH ADDICTION RESEARCH CENTER FROM HARRIS ISBELL RE SUPPLYING CORYNANTHINE
Document Type:
SPECIALCOLLECTION
Collection:
General CIA Records
Document Number (FOIA) /ESDN (CREST):
00151526
Release Decision:
RIPPUB
Original Classification:
U
Document Page Count:
1
Document Creation Date:
January 17, 2025
Document Release Date:
January 15, 1983
Sequence Number:
Case Number:
Publication Date:
July 21, 1954
File:
Attachment Size
PDF icon LETTER TO NIMH ADDICTION [12884480].pdf 38.84 KB
Body:
:TR EDUCATION, AND WE ZE PUBLIC HEALTH SERVICE IN RiPLYING. ADDRESS THZ N1MH Addiction Research Center, Lexington, Kentucky . 21 July 1954 - - Could you supply me with an additional amount of Corynanthine? We have not been able to show any significant --blocking effect when 15 mg. of this compound were administered 30 minutes prior fo 40 microcm of LSD-25. We are now giving 15 mg. every fwc hours for three doses. This, of course, means our consumption is rather high at this time. We have now c.ompleted the first trials on the effects of CA-10I on ihs'5cardiovascular response to standing. All 2 paiients sho:ozd marl(ed'el.vOion in pulse rate, a drco in both systolic and diastolic blood pressures, with marked narrowing of the pule pressure. This effect was evident two hours afr 2 moi of the drug had been given, appa red to be maximal eigh,t }.ours affcr the drug had been given, ,and were still present 16 sours after the drug. After r_IL hours. although responses were in the normal range,'hey were stili higher th_an'pre�drug controls. Very sincerely yours, � Q./ H3r1ris isbell, M.D. Director of Rese.arc% rn
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