It would make it much easier for them to attack her in any location if she were not familiar with it, but it was just as important that the surrounding environment could be used against her in many ways, with the most obvious use being to hide them, ready for an ambush.
There would always be times when she would have to pursue them if she lost sight of them, as it was possible that they would be on the move to somewhere else, and she could lose them even if they did not notice her.
If she were navigating around an unfamiliar environment, she would not be able to know where they were heading, and it would be much easier to lose them when in pursuit of them.
She would need to maintain a certain distance at times to prevent him from noticing, so she could lose sight of them if they were too far away from her.